New Cyclic Pentapeptides from the Mangrove-Derived Aspergillus fumigatus GXIMD 03099.
Mar Drugs
; 22(6)2024 Jun 16.
Article
in En
| MEDLINE
| ID: mdl-38921593
ABSTRACT
Four new cyclic pentapeptides, avellanins D-G (1-4), together with four known compounds (5-8), were isolated from a mangrove-derived Aspergillus fumigatus GXIMD 03099 fungus from Acanthus ilicifolius L. Their structures were elucidated by analysis of HRESIMS, NMR, and ESI-MS/MS data. Their absolute configurations were determined by X-ray diffraction analysis and Marfey's method. Compounds 1-8 were screened for insecticidal and antibacterial activities. Compound 2 showed insecticidal activity against newly hatched larvae of Culex quinquefasciatus with an LC50 value of 86.6 µM; compound 4 had weak activity against Vibrio harveyi with an MIC value of 5.85 µM.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Peptides, Cyclic
/
Aspergillus fumigatus
/
Microbial Sensitivity Tests
/
Insecticides
/
Anti-Bacterial Agents
Limits:
Animals
Language:
En
Journal:
Mar Drugs
Journal subject:
BIOLOGIA
/
FARMACOLOGIA
Year:
2024
Type:
Article
Affiliation country:
China