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Executive Summary: The Pediatric Extracorporeal Membrane Oxygenation Anticoagulation CollaborativE (PEACE) Consensus Conference.
Alexander, Peta M A; Bembea, Melania M; Cashen, Katherine; Cheifetz, Ira M; Dalton, Heidi J; Himebauch, Adam S; Karam, Oliver; Moynihan, Katie M; Nellis, Marianne E; Ozment, Caroline; Raman, Lakshmi; Rintoul, Natalie E; Said, Ahmed S; Saini, Arun; Steiner, Marie E; Thiagarajan, Ravi R; Watt, Kevin; Willems, Ariane; Zantek, Nicole D; Barbaro, Ryan P; Steffen, Katherine; Vogel, Adam M; Almond, Christopher; Anders, Marc M; Annich, Gail M; Brandão, Leonardo R; Chandler, Wayne; Delaney, Megan; DiGeronimo, Robert; Emani, Sitaram; Gadepalli, Samir K; Garcia, Alejandro V; Haileselassie, Bereketeab; Hyslop, Robert; Kneyber, Martin C J; Baumann Kreuziger, Lisa; Le, Jennifer; Loftis, Laura; McMichael, Ali B V; McMullan, D Michael; Monagle, Paul; Nicol, Kathleen; Paden, Matthew L; Patregnani, Jason; Priest, John; Raffini, Leslie; Ryerson, Lindsay M; Sloan, Steven R; Teruya, Jun; Yates, Andrew R.
Affiliation
  • Alexander PMA; Department of Cardiology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.
  • Bembea MM; Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Cashen K; Department of Pediatrics, Duke Children's Hospital, Duke University, Durham, NC.
  • Cheifetz IM; Department of Pediatrics, Rainbow Babies and Children's Hospital, Case Western Reserve University School of Medicine, Cleveland, OH.
  • Dalton HJ; Department of Pediatrics, INOVA Fairfax Medical Center, Falls Church, VA.
  • Himebauch AS; Department of Anesthesiology and Critical Care Medicine, Division of Critical Care Medicine, The Children's Hospital of Philadelphia, Perelman School of Medicine of the University of Pennsylvania, Philadelphia, PA.
  • Karam O; Division of Critical Care Medicine, Children's Hospital of Richmond at VCU, Richmond, VA.
  • Moynihan KM; Division of Critical Care Medicine, Yale School of Medicine, New Haven, CT.
  • Nellis ME; Department of Cardiology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.
  • Ozment C; Children's Hospital at Westmead Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, NSW, Australia.
  • Raman L; Department of Pediatrics, Division of Pediatric Critical Care Medicine, New York Presbyterian Hospital-Weill Cornell, New York, NY.
  • Rintoul NE; Division of Critical Care Medicine, Department of Pediatrics, Duke University and Duke University Health System, Durham, NC.
  • Said AS; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
  • Saini A; Department of Pediatrics, Division of Neonatology, Children's Hospital of Philadelphia, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA.
  • Steiner ME; Division of Pediatric Critical Care, Department of Pediatrics, Washington University in St. Louis, St. Louis, MO.
  • Thiagarajan RR; Department of Pediatrics, Section of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
  • Watt K; Department of Pediatrics, Divisions of Hematology and Critical Care, University of Minnesota, Minneapolis, MN.
  • Willems A; Department of Cardiology, Boston Children's Hospital, and Department of Pediatrics, Harvard Medical School, Boston, MA.
  • Zantek ND; Division of Clinical Pharmacology, Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT.
  • Barbaro RP; Pediatric Intensive Care Unit, Department of Intensive Care, Leiden University Medical Centre, Leiden, The Netherlands.
  • Steffen K; Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN.
  • Vogel AM; Division of Pediatric Critical Care Medicine, Department of Pediatrics, University of Michigan, Ann Arbor, MI.
  • Almond C; Department of Pediatrics (Pediatric Critical Care Medicine), Stanford University, Palo Alto, CA.
  • Anders MM; Departments of Surgery and Pediatrics, Texas Children's Hospital and Baylor College of Medicine, Houston, TX.
  • Annich GM; Department of Pediatrics (Cardiology), Stanford University School of Medicine, Palo Alto, CA.
  • Brandão LR; Department of Pediatrics, Section of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
  • Chandler W; Department of Critical Care Medicine, The Hospital for Sick Children, Toronto, ON, Canada.
  • Delaney M; Department of Pediatrics, The Hospital for Sick Children, Dalla Lana School of Public Health, University of Toronto, Toronto, ON, Canada.
  • DiGeronimo R; Department of Laboratories, Seattle Children's Hospital, Seattle, WA.
  • Emani S; Division of Pathology and Lab Medicine and Transfusion Medicine, Children's National Hospital, Washington, DC.
  • Gadepalli SK; Departments of Pathology and Pediatrics, The George Washington University Health Sciences, Washington, DC.
  • Garcia AV; Department of Pediatrics, Division of Neonatology, Seattle Children's Hospital, University of Washington School of Medicine, Seattle, WA.
  • Haileselassie B; Department of Cardiovascular Surgery, Boston Children's Hospital, and Department of Surgery, Harvard Medical School, Boston, MA.
  • Hyslop R; Division of Pediatric Surgery, Department of Surgery, University of Michigan, Ann Arbor, MI.
  • Kneyber MCJ; Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
  • Baumann Kreuziger L; Department of Pediatrics (Pediatric Critical Care Medicine), Stanford University, Palo Alto, CA.
  • Le J; Heart Institute, Children's Hospital of Colorado, Aurora, CO.
  • Loftis L; Department of Paediatrics, Division of Paediatric Critical Care Medicine, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
  • McMichael ABV; Versiti Blood Research Institute and Division of Hematology and Oncology, Medical College of Wisconsin, Milwaukee, WI.
  • McMullan DM; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, La Jolla, CA.
  • Monagle P; Department of Pediatrics, Section of Pediatric Critical Care Medicine, Texas Children's Hospital, Baylor College of Medicine, Houston, TX.
  • Nicol K; Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX.
  • Paden ML; Department of Pediatrics, Phoenix Children's Hospital, Phoenix, AZ.
  • Patregnani J; Division of Pediatric Cardiac Surgery, Seattle Children's Hospital, Seattle, WA.
  • Priest J; University of Melbourne, and Kids Cancer Centre Sydney Children's Hospital, and Murdoch Children's Research Institute, and Royal Children's Hospital Melbourne Australia, Melbourne, VIC, Australia.
  • Raffini L; Department of Pathology, Nationwide Children's Hospital, Columbus, OH.
  • Ryerson LM; Children's Healthcare of Atlanta, Emory University School of Medicine, Atlanta, GA.
  • Sloan SR; Department of Pediatrics, Division of Pediatric Critical Care Medicine, Barbara Bush Children's Hospital, Portland, ME.
  • Teruya J; Department of Respiratory Care, Boston Children's Hospital, Boston MA.
  • Yates AR; Department of Pediatrics, Division of Hematology, The Children's Hospital of Philadelphia, University of Pennsylvania, Philadelphia, PA.
Pediatr Crit Care Med ; 25(7): 643-675, 2024 Jul 01.
Article in En | MEDLINE | ID: mdl-38959353
ABSTRACT

OBJECTIVES:

To present recommendations and consensus statements with supporting literature for the clinical management of neonates and children supported with extracorporeal membrane oxygenation (ECMO) from the Pediatric ECMO Anticoagulation CollaborativE (PEACE) consensus conference. DATA SOURCES Systematic review was performed using PubMed, Embase, and Cochrane Library (CENTRAL) databases from January 1988 to May 2021, followed by serial meetings of international, interprofessional experts in the management ECMO for critically ill children. STUDY SELECTION The management of ECMO anticoagulation for critically ill children. DATA EXTRACTION Within each of eight subgroup, two authors reviewed all citations independently, with a third independent reviewer resolving any conflicts. DATA

SYNTHESIS:

A systematic review was conducted using MEDLINE, Embase, and Cochrane Library databases, from January 1988 to May 2021. Each panel developed evidence-based and, when evidence was insufficient, expert-based statements for the clinical management of anticoagulation for children supported with ECMO. These statements were reviewed and ratified by 48 PEACE experts. Consensus was obtained using the Research and Development/UCLA Appropriateness Method. Results were summarized using the Grading of Recommendations Assessment, Development, and Evaluation method. We developed 23 recommendations, 52 expert consensus statements, and 16 good practice statements covering the management of ECMO anticoagulation in three broad categories general care and monitoring; perioperative care; and nonprocedural bleeding or thrombosis. Gaps in knowledge and research priorities were identified, along with three research focused good practice statements.

CONCLUSIONS:

The 91 statements focused on clinical care will form the basis for standardization and future clinical trials.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Extracorporeal Membrane Oxygenation / Critical Illness / Anticoagulants Limits: Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: Pediatr Crit Care Med Journal subject: PEDIATRIA / TERAPIA INTENSIVA Year: 2024 Type: Article Affiliation country: Morocco
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Extracorporeal Membrane Oxygenation / Critical Illness / Anticoagulants Limits: Child / Child, preschool / Humans / Infant / Newborn Language: En Journal: Pediatr Crit Care Med Journal subject: PEDIATRIA / TERAPIA INTENSIVA Year: 2024 Type: Article Affiliation country: Morocco