The biological variation of insulin resistance markers: data from the European Biological Variation Study (EuBIVAS).
Clin Chem Lab Med
; 2024 Jul 12.
Article
in En
| MEDLINE
| ID: mdl-38987271
ABSTRACT
OBJECTIVES:
An insulin resistant state is characteristic of patients with type 2 diabetes, polycystic ovary syndrome, and metabolic syndrome. Identification of insulin resistance (IR) is most readily achievable using formulae combining plasma insulin and glucose results. In this study, we have used data from the European Biological Variation Study (EuBIVAS) to examine the biological variability (BV) of IR using the Homeostasis Model Assessment for Insulin Resistance (HOMA-IR) and the Quantitative Insulin sensitivity Check Index (QUICKI).METHODS:
Ninety EuBIVAS non-diabetic subjects (52F, 38M) from five countries had fasting HOMA-IR and QUICKI calculated from plasma glucose and insulin samples collected concurrently on 10 weekly occasions. The within-subject (CVI) and between-subject (CVG) BV estimates with 95â¯% CIs were obtained by CV-ANOVA after analysis of trends, variance homogeneity and outlier removal.RESULTS:
The CVI of HOMA-IR was 26.7â¯% (95â¯% CI 25.5-28.3), driven largely by variability in plasma insulin and the CVI for QUICKI was 4.1â¯% (95â¯% CI 3.9-4.3), reflecting this formula's logarithmic transformation of glucose and insulin values. No differences in values or BV components were observed between subgroups of men or women below and above 50 years.CONCLUSIONS:
The EuBIVAS, by utilising a rigorous experimental protocol, has produced robust BV estimates for two of the most commonly used markers of insulin resistance in non-diabetic subjects. This has shown that HOMA-IR, in particular, is highly variable in the same individual which limits the value of single measurements.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Language:
En
Journal:
Clin Chem Lab Med
Journal subject:
QUIMICA CLINICA
/
TECNICAS E PROCEDIMENTOS DE LABORATORIO
Year:
2024
Type:
Article
Affiliation country:
Italy