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Combined Application of Cold Physical Plasma and Chemotherapeutics against Chondrosarcoma Cells.
Nitsch, Andreas; Qarqash, Sara; Schulze, Frank; Nonnenmacher, Lars; Bekeschus, Sander; Tzvetkov, Mladen V; Wassilew, Georgi I; Haralambiev, Lyubomir.
Affiliation
  • Nitsch A; Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
  • Qarqash S; Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
  • Schulze F; Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
  • Nonnenmacher L; Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
  • Bekeschus S; ZIK Plasmatis, Leibniz Institute for Plasma Science and Technology (INP), Felix-Hausdorff-Straße 2, 17489 Greifswald, Germany.
  • Tzvetkov MV; Clinic and Policlinic for Dermatology and Venerology, Rostock University Medical Center, Strempelstr. 13, 18057 Rostock, Germany.
  • Wassilew GI; Department of General Pharmacology, Institute of Pharmacology, Center of Drug Absorption and Transport (C_DAT), University Medicine Greifswald, 17487 Greifswald, Germany.
  • Haralambiev L; Center for Orthopedics, Trauma Surgery and Rehabilitation Medicine, University Medicine Greifswald, Ferdinand-Sauerbruch-Str., 17475 Greifswald, Germany.
Int J Mol Sci ; 25(13)2024 Jun 25.
Article in En | MEDLINE | ID: mdl-39000064
ABSTRACT
Chondrosarcoma (CS) is a rare malignant bone sarcoma that primarily affects cartilage cells in the femur and pelvis. While most subtypes exhibit slow growth with a very good prognosis, some aggressive subtypes have a poorer overall survival. CS is known for its resistance to chemotherapy and radiotherapy, leaving surgery as the sole effective therapeutic option. Cold physical plasma (CPP) has been explored in vitro as a potential therapy, demonstrating positive anti-tumor effects on CS cells. This study investigated the synergistic effects of combining CPP with cytostatics on CS cells. The chemotherapeutic agents cisplatin, doxorubicin, and vincristine were applied to two CS cell lines (CAL-78 and SW1353). After determining their IC20 and IC50, they were combined with CPP in both cell lines to assess their impact on the cell proliferation, viability, metabolism, and apoptosis. This combined approach significantly reduced the cell proliferation and viability while increasing the apoptosis signals compared to cytostatic therapy alone. The combination of CPP and chemotherapeutic drugs shows promise in targeting chemoresistant CS cells, potentially improving the prognosis for patients in clinical settings.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Doxorubicin / Cell Survival / Chondrosarcoma / Apoptosis / Cell Proliferation / Plasma Gases Limits: Humans Language: En Journal: Int J Mol Sci Year: 2024 Type: Article Affiliation country: Germany

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Bone Neoplasms / Doxorubicin / Cell Survival / Chondrosarcoma / Apoptosis / Cell Proliferation / Plasma Gases Limits: Humans Language: En Journal: Int J Mol Sci Year: 2024 Type: Article Affiliation country: Germany