Effect of incremental tazobactam concentrations on the bactericidal activity of piperacillin against ESBL-producing enterobacterales clinical isolates causing bacteraemia.
Eur J Clin Microbiol Infect Dis
; 43(9): 1861-1864, 2024 Sep.
Article
in En
| MEDLINE
| ID: mdl-39017998
ABSTRACT
We evaluated the activity of piperacillin in relation to INCREASING TAZOBACTAM CONCENTRATION against ESBL-producing Enterobacterales collected from patients with bacteraemia. Increasing tazobactam concentration (4, 12 or 24 mg/L) exerted a reduction of piperacillin MICs under the clinical breakpoint in a concentration-dependent manner (0%, 60% and 90% of clinical isolates). Also, activity of piperacillin/tazobactam based at higher achievable serum concentrations (123/14 mg/L) is needed to reduce the bacterial growth in 92% of ESBL-producers. CHANGES IN THE PIPERACILLIN MIC IN RELATION TO INCREASING TAZOBACTAM SUGGEST THAT REALTIME TDM COULD BE USED FOR DRIVEN ANTIMICROBIAL THERAPY WITH PIPERACILLIN/TAZOBACTAM IN BSI DUE TO ESBL STRAINS.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Piperacillin
/
Beta-Lactamases
/
Microbial Sensitivity Tests
/
Bacteremia
/
Enterobacteriaceae
/
Enterobacteriaceae Infections
/
Tazobactam
/
Anti-Bacterial Agents
Limits:
Humans
Language:
En
Journal:
Eur J Clin Microbiol Infect Dis
/
Eur. j. clin. microbiol. infect. dis
/
European journal of clinical microbiology and infectious diseases
Journal subject:
DOENCAS TRANSMISSIVEIS
/
MICROBIOLOGIA
Year:
2024
Type:
Article
Affiliation country:
Italy