Hemophagocytic lymphohistiocytosis induced by dabrafenib-trametinib in a patient with metastatic melanoma: a case report and pharmacovigilance analysis.
Melanoma Res
; 34(5): 465-468, 2024 10 01.
Article
in En
| MEDLINE
| ID: mdl-39037717
ABSTRACT
Hemophagocytic lymphohistiocytosis (HLH) has been reported rarely with BRAF/MEK inhibitor combinations, including dabrafenib/trametinib. Postmarketing pharmacovigilance analyses evaluating outcomes associated with dabrafenib/trametinib-induced HLH are also lacking. Herein, we report a case of dabrafenib/trametinib-induced HLH in a patient with metastatic melanoma. Recovery of HLH-related symptoms was observed following drug discontinuation, supportive care, and corticosteroids. We also conducted a pharmacovigilance analysis of the USA Food and Drug Administration Adverse Event Reporting System (FAERS) to describe postmarketing cases of HLH with dabrafenib/trametinib exposure. There were 50 reports of HLH with dabrafenib/trametinib in FAERS. Most cases occurred in the setting of melanoma ( n â
=â
39; 78%) and most were reported in Europe ( n â
=â
39; 74%). Hospitalization was the most common outcome ( n â
=â
39; 78%) of this adverse event per FAERS. HLH is a rare complication of dabrafenib/trametinib, and clinicians should be aware and monitor for signs of this potentially serious and life-threatening adverse event.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oximes
/
Pyridones
/
Pyrimidinones
/
Lymphohistiocytosis, Hemophagocytic
/
Imidazoles
/
Melanoma
Limits:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Melanoma Res
Journal subject:
NEOPLASIAS
Year:
2024
Type:
Article