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Diagnostic potential of IL6 and other blood-based inflammatory biomarkers in mild traumatic brain injury among children.
Chiollaz, Anne-Cécile; Pouillard, Virginie; Habre, Céline; Seiler, Michelle; Romano, Fabrizio; Spigariol, Fabian; Ritter Schenk, Céline; Korff, Christian; Maréchal, Fabienne; Wyss, Verena; Gruaz, Lyssia; Montaner, Joan; Manzano, Sergio; Sanchez, Jean-Charles.
Affiliation
  • Chiollaz AC; Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Pouillard V; Pediatric Neurology Unit, Department of the Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland.
  • Habre C; Division of Radiology, University Hospitals of Geneva, Geneva, Switzerland.
  • Seiler M; Department of Pediatric Emergency, University Children's Hospital Zurich, Zürich, Switzerland.
  • Romano F; Division of Pediatric Emergency Medicine, Department of Pediatrics, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
  • Spigariol F; Department of Pediatric Emergency, Neuchâtel Hospital (RHNE), Neuchâtel, Switzerland.
  • Ritter Schenk C; Department of Pediatrics, Fribourg Hospital HFR, Fribourg, Switzerland.
  • Korff C; Pediatric Neurology Unit, Department of the Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland.
  • Maréchal F; Platform of Pediatric Clinical Research, Department of Woman, Child and Adolescent, Geneva University Hospitals, Geneva, Switzerland.
  • Wyss V; Department of Pediatric Emergency, University Children's Hospital Zurich, Zürich, Switzerland.
  • Gruaz L; Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Montaner J; Neurovascular Research Group, Institute of Biomedicine of Seville, IBiS/Virgen Macarena University Hospital/CSIC/University of Seville, Seville, Spain.
  • Manzano S; Department of Pediatric Emergency, Geneva University Hospitals and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
  • Sanchez JC; Department of Internal Medicine, Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Front Neurol ; 15: 1432217, 2024.
Article in En | MEDLINE | ID: mdl-39055316
ABSTRACT

Objectives:

Inflammatory biomarkers, as indicators of biological states, provide a valuable approach for accurate and reproducible measurements, crucial for the effective management of mild traumatic brain injury (mTBI) in pediatric patients. This study aims to assess the diagnostic utility of blood-based inflammatory markers IL6, IL8, and IL10 in children with mTBI, including those who did not undergo computed tomography (CT) scans.

Methods:

A prospective multicentric cohort study involving 285 pediatric mTBI patients was conducted, stratified into CT-scanned and non-CT-scanned groups within 24 h post-trauma, alongside 74 control subjects. Biomarker levels were quantitatively analyzed using ELISA. Sensitivity and specificity metrics were calculated to determine the diagnostic efficacy of each biomarker.

Results:

A total of 223 mTBI patients (78%) did not undergo CT scan examination but were kept in observation for symptoms monitoring at the emergency department (ED) for more than 6 h (in-hospital-observation patients). Among CT-scanned patients (n = 62), 14 (23%) were positive (CT+). Elevated levels of IL6 and IL10 were found in mTBI children compared to controls. Within mTBI patients, IL6 was significantly increased in CT+ patients compared to both CT- and in-hospital-observation patients. No significant differences were observed for IL8 among the compared groups. IL6 yielded a specificity of 48% in identifying CT- and in-hospital-observation patients, with 100% sensitivity in excluding all CT+ cases. These performances were maintained whether IL6 was measured within 6 h or within 24 h after the trauma.

Conclusion:

The inflammatory marker IL6 emerges as a robust biomarker, showing promising stratification value for pediatric mTBI patients undergoing CT scans or staying in observation in a pediatric ED.
Key words

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Neurol Year: 2024 Type: Article Affiliation country: Switzerland

Full text: 1 Collection: 01-internacional Database: MEDLINE Language: En Journal: Front Neurol Year: 2024 Type: Article Affiliation country: Switzerland