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GABA system in the prefrontal cortex involved in psychostimulant addiction.
Shi, Wenjing; Li, Minyu; Zhang, Ting; Yang, Chunlong; Zhao, Dongdong; Bai, Jie.
Affiliation
  • Shi W; Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
  • Li M; Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
  • Zhang T; Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
  • Yang C; Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
  • Zhao D; Medical School, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
  • Bai J; Faculty of Life Science and Technology, Kunming University of Science and Technology, No. 727 Jingming South Road, Kunming 650500, Yunnan, China.
Cereb Cortex ; 34(8)2024 Aug 01.
Article in En | MEDLINE | ID: mdl-39098820
ABSTRACT
Drug addiction is a chronic and relapse brain disorder. Psychostimulants such as cocaine and amphetamine are highly addictive drugs. Abuse drugs target various brain areas in the nervous system. Recent studies have shown that the prefrontal cortex (PFC) plays a key role in regulating addictive behaviors. The PFC is made up of excitatory glutamatergic cells and gamma-aminobutyric acid (GABAergic) interneurons. Recently, studies showed that GABA level was related with psychostimulant addiction. In this review, we will introduce the role and mechanism of GABA and γ-aminobutyric acid receptors (GABARs) of the PFC in regulating drug addiction, especially in psychostimulant addiction.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prefrontal Cortex / Substance-Related Disorders / Gamma-Aminobutyric Acid / Central Nervous System Stimulants Limits: Animals / Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2024 Type: Article Affiliation country: China
Fulltext
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prefrontal Cortex / Substance-Related Disorders / Gamma-Aminobutyric Acid / Central Nervous System Stimulants Limits: Animals / Humans Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2024 Type: Article Affiliation country: China