Occupations and the risk of buccal mucosa cancer in Indian men: A multi-centre case-control study.
Cancer Epidemiol
; 92: 102644, 2024 Oct.
Article
in En
| MEDLINE
| ID: mdl-39153274
ABSTRACT
OBJECTIVE:
This study aimed to investigate the association between lifetime occupational history and risk of buccal mucosa cancer (BMC).METHODS:
We utilized a multi-centric, hospital-based case-control study across five centres of Tata Memorial Centre, Mumbai, India. Cases included men aged 20-75-years with histological confirmed primary cancer of the buccal mucosa. Visitor controls were frequency matched to cases for age (10 years interval) and current residential zone. Study participants were interviewed face-to-face. Logistic regression was performed to estimate odds ratio (OR) and 95â¯% confidence intervals (CI).RESULTS:
Among ever employed males, we identified 1969 BMC cases and 2145 controls. We observed an increased risk of BMC in 'Craft and Related Trades Workers' (OR 1.37; 95â¯% CI 1.13-1.65), 'Plant and Machine Operators and Assemblers' (OR 1.26; 95â¯% CI 1.01-1.56), and 'Elementary Occupations' (OR1.33; 95â¯% CI 1.12-1.58). More specifically, the increased risk was observed for 'Metal, Machinery and Related Trades Workers', 'Handicraft and Printing Workers', 'Drivers and Mobile Plant Operators', and 'Laborers in Mining, Construction, Manufacturing and Transport'.CONCLUSION:
Our findings suggest that certain occupations may be at a higher risk of BMC. Some fraction of BMC can be prevented by reducing exposure to hazardous agents used in these occupations. Further research is needed to identify which exposures are responsible for the increased risk. Moreover, tobacco control and early detection activities can be focused towards these occupations as tobacco consumption is also high in them, which may also be the reason for increased risk observed in these groups.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Mouth Neoplasms
/
Occupational Exposure
/
Mouth Mucosa
/
Occupations
Limits:
Adult
/
Aged
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
Cancer Epidemiol
/
Cancer epidemiol
/
Cancer epidemiology
Journal subject:
EPIDEMIOLOGIA
/
NEOPLASIAS
Year:
2024
Type:
Article
Affiliation country:
India