Chrysin downregulates the expression of ADAMTS-4 in foam cells.
Mol Biol Rep
; 51(1): 968, 2024 Sep 09.
Article
in En
| MEDLINE
| ID: mdl-39249599
ABSTRACT
BACKGROUND:
Chrysin, a polyphenolic compound, possesses antioxidant and anti-inflammatory properties. In this study, we investigated the effect of chrysin on the expression of A disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4), a protease enzyme involved in degrading extracellular matrix associated with atherosclerosis. METHODS ANDRESULTS:
We have studied the cell viability by MTT assay and foam cell formation by oil red O staining. The mRNA and protein expression of ADAMTS-4 was studied using quantitative polymerase chain reaction (qPCR) and Western blotting, respectively. Our study showed that chrysin significantly downregulates the expression of ADAMTS-4 in foam cells.CONCLUSION:
Chrysin's ability to downregulate the expression of ADAMTS-4, a protease involved in degrading the extracellular matrix, bestows upon it a new therapeutic potential for managing atherosclerosis.Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Flavonoids
/
Down-Regulation
/
Foam Cells
/
ADAMTS4 Protein
Limits:
Humans
Language:
En
Journal:
Mol Biol Rep
Year:
2024
Type:
Article
Affiliation country:
India