RNA and condensates: Disease implications and therapeutic opportunities.
Cell Chem Biol
; 31(9): 1593-1609, 2024 Sep 19.
Article
in En
| MEDLINE
| ID: mdl-39303698
ABSTRACT
Biomolecular condensates are dynamic membraneless organelles that compartmentalize proteins and RNA molecules to regulate key cellular processes. Diverse RNA species exert their effects on the cell by their roles in condensate formation and function. RNA abnormalities such as overexpression, modification, and mislocalization can lead to pathological condensate behaviors that drive various diseases, including cancer, neurological disorders, and infections. Here, we review RNA's role in condensate biology, describe the mechanisms of RNA-induced condensate dysregulation, note the implications for disease pathogenesis, and discuss novel therapeutic strategies. Emerging approaches to targeting RNA within condensates, including small molecules and RNA-based therapies that leverage the unique properties of condensates, may revolutionize treatment for complex diseases.
Key words
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
RNA
/
Biomolecular Condensates
Limits:
Animals
/
Humans
Language:
En
Journal:
Cell Chem Biol
Year:
2024
Type:
Article
Affiliation country:
United States