Selective luminal absorption of L-carnitine from the proximal regions of the rat epididymis. Possible relationships to development of sperm motility.
J Androl
; 6(5): 300-5, 1985.
Article
in En
| MEDLINE
| ID: mdl-4055529
ABSTRACT
The absorption of L-carnitine from the duct of the proximal regions of the rat epididymis was investigated using a stopped-flow, split-droplet microperfusion technique. L-carnitine was absorbed from the duct of the proximal caput epididymidis by a time-dependent and saturable transport system (Km = 25 micron; Vmax = 0.65 pmoles absorbed/min/mm3 tubular volume). Furthermore, absorption appeared to be primarily sodium-independent, although the existence of a minor sodium-dependent pathway cannot be ruled out. A similar transport system was not evident along the distal caput epididymidis, where absorption of L-carnitine was attributable to passive diffusion only. The inward and outward movement of L-carnitine across the epithelium of the proximal and distal caput epididymidis appears to be regulated so that the spermatozoa come into contact with high levels of L-carnitine in the distal caput region.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Sperm Motility
/
Carnitine
/
Epididymis
Limits:
Animals
Language:
En
Journal:
J Androl
Year:
1985
Type:
Article