In vivo growth advantage of the MOPC-315 mouse myeloma over its immunoselected variants.
J Natl Cancer Inst
; 59(4): 1307-10, 1977 Oct.
Article
in En
| MEDLINE
| ID: mdl-409851
ABSTRACT
Myeloma cells of the "wild type" that produce complete immunoglobulin molecules and those of the more usual variant type that display only one kind of chain [either light (L) or heavy (H)] were cocultivated ip and sc in syngeneic BALB/c mice. With each of six deliberately selected variants, a progressive increase in the proportion of wild-type cells was observed; the rate of change suggested that these variants had an approximately 10% slower growth rate than that of the wild-type tumor. In contrast, a variant that arose spontaneously overgrew the wild-type cells. The results may account for a) the stable capacity of most wild-type tumors to produce complete immunoglobulin molecules (L- plus H-chains) over many years, even though they frequently generate variant cells that produce only L- or only H-chains; and b) the occasional spontaneous change of myeloma cell populations from predominantly wild-type to variant cells.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Selection, Genetic
/
Genetic Variation
/
Immunoglobulin alpha-Chains
/
Immunoglobulin Heavy Chains
/
Immunoglobulin lambda-Chains
/
Immunoglobulin Light Chains
/
Multiple Myeloma
Limits:
Animals
Language:
En
Journal:
J Natl Cancer Inst
Year:
1977
Type:
Article