Renal actions of oxyphenbutazone.
J Pharm Sci
; 68(9): 1178-9, 1979 Sep.
Article
in En
| MEDLINE
| ID: mdl-501546
ABSTRACT
Oxyphenbutazone decreased the renal excretion of sodium and water in anesthetized dogs. As these excretions decreased, the drug also produced a decrease in renal blood flow and in the glomerular filtration rate. Blood pressure increased slightly. These changes are consistent with an inhibition of renal prostaglandin synthesis and could explain why oxyphenbutazone is reported to produce weight gain and edema when used clinically.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Oxyphenbutazone
/
Kidney
Limits:
Animals
Language:
En
Journal:
J Pharm Sci
Year:
1979
Type:
Article