Membranes in polyribosome formation by rabbit reticulocytes.
Science
; 157(3786): 323-5, 1967 Jul 21.
Article
in En
| MEDLINE
| ID: mdl-6028402
ABSTRACT
When rabbit reticulocytes are incubated with n-butanol, an agent disruptive to the structure and function of cellular membranes, there is a rapid disaggregation of the polyribosomes. Reaggregation is promoted when the n-butanol is diluted below a critical concentration or when the cells are washed free of the alcohol and the incubation is continued. Neither disaggregation nor regeneration will occur in the absence of protein synthesis. These observations suggest that integrity of the reticulocyte membrane is necessary for the attachment of ribosomes to messenger RNA and for the formation of polyribosomes.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Reticulocytes
/
Ribosomes
/
Cell Membrane
/
Alcohols
Limits:
Animals
Language:
En
Journal:
Science
Year:
1967
Type:
Article