Delineation of an immunoregulatory amplifier population recognizing autologous Ia molecules. Analysis with human T cell clones.
J Exp Med
; 159(2): 559-76, 1984 Feb 01.
Article
in En
| MEDLINE
| ID: mdl-6198432
ABSTRACT
Autoreactive T lymphocytes were generated by culturing human peripheral blood mononuclear cells with an antigen-specific major histocompatibility complex (MHC)-restricted autologous inducer T cell, termed RW17C and subsequently cloned in soft agar. The majority of such clones (AC1-13) expressed the T3+T4+T8-T11+Ia+ phenotype and were directed at autologous class II MHC gene products found on B cells, macrophages, and B lymphoblastoid cells as judged by their proliferative response to the latter. For this recognition, the clones employed a T3-Ti molecular complex and a T4 structure analogous to those found on allospecific T cells. Perhaps more importantly, it was observed that the same AC1-13 autoreactive clones (AC) induced autologous B cells to produce high levels of immunoglobulin in the absence of exogenous antigen and could synergize with the RW17C clone to effect maximal B cell Ig production. These results support the notion that such autoreactive cells can function in a physiologic amplifier role by facilitating induction via an internal set of signals (i.e. autologous MHC).
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Plant Proteins
/
Allergens
/
Receptors, Antigen, T-Cell
/
Histocompatibility Antigens Class II
/
T-Lymphocytes, Helper-Inducer
Limits:
Humans
Language:
En
Journal:
J Exp Med
Year:
1984
Type:
Article