Inhibition of non-specific leukocyte esterase activity. Absence of monocyte esterase activity due to phosphoric and thiophosphoric acid ester intoxication.
Forensic Sci Int
; 25(3): 181-9, 1984 Jul.
Article
in En
| MEDLINE
| ID: mdl-6378740
ABSTRACT
In vitro evaluation of the effect of five insecticidal phosphoric and 11 thiophosphoric acid esters on different, non-specific human leukocytes esterases indicated that most of the organic phosphor compounds studied inhibited the activity of neutral alpha-naphthylacetate esterase, alpha-naphthylbutyryl esterase, and naphthol AS acetate esterase, i.e. the monocyte esterases. The extent of inhibition was dose dependent; the inhibiting dose being identical for the various non-specific esterases. Reactivation with Obidoxim was not successful. Monocyte esterase activity in a human survivor of E 605 intoxication was detectable only after serum acetylcholinesterase had returned to normal levels. The organic phosphor compound studied, however, inhibited neither acid alpha-naphthylacetate esterase nor naphthol AS-D chloroacetate esterase activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Monocytes
/
Esterases
/
Insecticides
/
Leukocytes
Limits:
Adolescent
/
Female
/
Humans
Language:
En
Journal:
Forensic Sci Int
Year:
1984
Type:
Article