Chemotherapy of childhood rhabdomyosarcomas growing as xenografts in immune-deprived mice.
Cancer Res
; 42(2): 535-9, 1982 Feb.
Article
in En
| MEDLINE
| ID: mdl-7034923
ABSTRACT
Xenografts derived from the neoplastic tissues of children with rhabdomyosarcoma have been used in immune-deprived mice to examine the efficacy of agents known to be active against this disease, and in others that received either limited or no clinical evaluation. Two models were derived; xenografts were established from tumors obtained from either (a) untreated patients or (b) from patients who had become refractory to conventional therapy. Model a identified as being effective each of these clinically used agents vincristine, dactinomycin, cyclophosphamide, and doxorubicin; mitomycin C and 5-(3,3-dimethyl-1-triazeno)-2-methylimidazole-4-carboxamide also showed activity, as did busulfan in one tumor line. Tumors derived from refractory patients were significantly less responsive to all agents examined.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Rhabdomyosarcoma
/
Antineoplastic Agents
Type of study:
Prognostic_studies
Limits:
Animals
/
Child
/
Female
/
Humans
Language:
En
Journal:
Cancer Res
Year:
1982
Type:
Article