On the interaction of diazepam with human, rat and mouse plasma proteins and erythrocytes.
Biochem Pharmacol
; 31(7): 1455-8, 1982 Apr 01.
Article
in En
| MEDLINE
| ID: mdl-7092935
ABSTRACT
Binding of diazepam to the blood fractions (erythrocytes and plasma proteins) in man, rat and mouse was studied. Only little dependence of binding on total drug concentration was found. The main binding fraction of plasma in studied species is albumin, but interspecies differences are both in the amount of diazepam bound to albumin and in that bound to other components of plasma. The determination of the binding of diazepam with erythrocytic mass and with blood plasma demonstrates the proportion of these bonds in total distribution of the drug under study in blood and the importance of thus experimentally followed interspecies comparison.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Blood Proteins
/
Diazepam
/
Erythrocytes
Limits:
Adolescent
/
Adult
/
Animals
/
Humans
/
Male
Language:
En
Journal:
Biochem Pharmacol
Year:
1982
Type:
Article