Niemann-Pick disease: a genetic model in Siamese cats.
Science
; 208(4451): 1471-3, 1980 Jun 27.
Article
in En
| MEDLINE
| ID: mdl-7189903
ABSTRACT
Three Siamese cats were found to have a progressive neurological disease that became obvious when they were 4 to 5 months of age. Their brains contained an excess of GM2 and GM3 gangliosides, and their livers a nine- to tenfold excess of sphingomyelin and cholesterol. A total deficiency of lysosomal (pH 5.0) sphingomyelinase was found in the leukocytes, liver, and brain of the cats, although the activity of the microsomal (pH 7.4, magnesium-dependent) sphingomyelinase was normal in brain. These cats appear to have a genetic disease identical to Niemann-Pick disease type A.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Cat Diseases
/
Niemann-Pick Diseases
/
Disease Models, Animal
Limits:
Animals
/
Humans
Language:
En
Journal:
Science
Year:
1980
Type:
Article