Synthesis and anticholinergic properties of the enantiomers of 4-(isopropylamino)-2-(2-pyridyl)-2-phenylbutyramide, the mono-N-dealkylated metabolite of disopyramide.

Nelson, W L; Sneed, C K; Giacomini, K M; Giacomini, J C; Stauss, J; Blaschke, T F; Cox, B M

Nelson, W L; Sneed, C K; Giacomini, K M; Giacomini, J C; Stauss, J; Blaschke, T F; Cox, B M.

J Med Chem ; 24(5): 614-7, 1981 May.

Article in En | MEDLINE | ID: mdl-7241519

Subject(s)

Disopyramide/chemical synthesis; Disopyramide/metabolism; Parasympatholytics/chemical synthesis; Pyridines/chemical synthesis; Pyridines/metabolism; Acetylcholine/pharmacology; Animals; Chemical Phenomena; Chemistry; Disopyramide/analogs & derivatives; Disopyramide/pharmacology; Dose-Response Relationship, Drug; Electric Stimulation; Guinea Pigs; Histamine/pharmacology; In Vitro Techniques; Muscle Contraction/drug effects; Muscle, Smooth/drug effects; Stereoisomerism

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Collection: 01-internacional Database: MEDLINE Main subject: Parasympatholytics / Pyridines / Disopyramide Limits: Animals Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1981 Type: Article

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