Chlorzoxazone is metabolized by human CYP1A2 as well as by human CYP2E1.

Ono, S; Hatanaka, T; Hotta, H; Tsutsui, M; Satoh, T; Gonzalez, F J

Ono, S; Hatanaka, T; Hotta, H; Tsutsui, M; Satoh, T; Gonzalez, F J.

Affiliation

Ono S; Central Laboratory for Research and Development, Amersham K.K., Chiba, Japan.

Pharmacogenetics ; 5(3): 143-50, 1995 Jun.

Article in En | MEDLINE | ID: mdl-7550365

Subject(s)

Chlorzoxazone/metabolism; Cytochrome P-450 Enzyme System/metabolism; Oxidoreductases, N-Demethylating/metabolism; Oxidoreductases/metabolism; Benzoflavones/pharmacology; Cytochrome P-450 CYP1A2; Cytochrome P-450 CYP2E1; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System/genetics; Ditiocarb/pharmacology; Humans; Hydroxylation; Microsomes, Liver/enzymology; Oxidoreductases/antagonists & inhibitors; Oxidoreductases/genetics; Oxidoreductases, N-Demethylating/antagonists & inhibitors; Oxidoreductases, N-Demethylating/genetics; Recombinant Proteins/genetics; Recombinant Proteins/metabolism; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Oxidoreductases / Oxidoreductases, N-Demethylating / Chlorzoxazone / Cytochrome P-450 Enzyme System Limits: Humans Language: En Journal: Pharmacogenetics Year: 1995 Type: Article Affiliation country: Japan

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