Plasma 8-epi-PGF2 alpha levels are elevated in individuals with non-insulin dependent diabetes mellitus.
FEBS Lett
; 368(2): 225-9, 1995 Jul 17.
Article
in En
| MEDLINE
| ID: mdl-7628610
ABSTRACT
This study reports plasma levels of a specific nonenzymatic peroxidation product of arachidonic acid, esterified 8-epi-PGF2 alpha, from healthy- and NIDDM individuals as an index of oxidative stress in vivo. Plasma 8-epi-PGF2 alpha was isolated by solid-phase extraction on a C18 followed by an NH2 cartridge and analyzed by GC-MS/NICI as PFB-ester/TMS-ether derivative. We found that the average concentration of esterified 8-epi-PGF2 alpha among NIDDM subjects (0.93 +/- 0.07 nM, n = 39) was higher (P < 0.0001, Mann-Whitney test) than in healthy individuals (0.28 +/- 0.04 nM, n = 15). These data indicate that NIDDM is associated with increased plasma lipid peroxidation.
Search on Google
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Dinoprost
/
Diabetes Mellitus, Type 2
Limits:
Adult
/
Humans
Language:
En
Journal:
FEBS Lett
Year:
1995
Type:
Article
Affiliation country:
United kingdom