Carotenoids located in human lymphocyte subpopulations and natural killer cells by Raman microspectroscopy.
Cytometry
; 14(3): 251-6, 1993.
Article
in En
| MEDLINE
| ID: mdl-7682491
ABSTRACT
The presence and subcellular location of carotenoids in human lymphocyte subpopulations (CD4+, CD8+, T-cell receptor-gamma delta+, and CD19+) and natural killer cells (CD16+) were studied by means of Raman microspectroscopy. In CD4+ lymphocytes a high concentration (approximately 10(-3) M) of carotenoids was found in the Gall body. In CD8+ lymphocytes, T-cell-receptor-gamma delta+ lymphocytes and in natural killer cells carotenoids appeared to be concentrated (approximately 10(-4) M) in the Golgi complex. The concentration of carotenoids in CD19+ lymphocytes was found to be below the present detection limit, which is approximately 10(-6) to 10(-5) M. The results provide new possibilities to investigate the mechanism(s) behind the suggested protective role of carotenoids against the development of cancers.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Killer Cells, Natural
/
Carotenoids
/
Lymphocyte Subsets
Limits:
Humans
Language:
En
Journal:
Cytometry
Year:
1993
Type:
Article
Affiliation country:
Netherlands