The results of in vitro fertilization-embryo transfer in couples with unexplained infertility failing to conceive with superovulation and intrauterine insemination.
Fertil Steril
; 64(1): 93-7, 1995 Jul.
Article
in En
| MEDLINE
| ID: mdl-7789586
ABSTRACT
OBJECTIVE:
To determine the results of IVF-ET in couples with long-standing unexplained infertility who had failed to conceive with four to six cycles of superovulation and IUI.DESIGN:
Retrospective case control series.SETTING:
University IVF-ET center. PATIENTS One hundred seventeen couples with unexplained infertility who had failed to conceive with superovulation and IUI underwent 157 cycles of IVF-ET. Results were compared with 194 tubal factor couples subjected to 250 IVF-ET cycles within the same time period.RESULTS:
Total fertilization failure events were more common (20.4% versus 7.6%) and tended to be repetitive in couples with unexplained infertility. When total fertilization failure events were excluded, fertilization rates (57.8% versus 60.9%) and cumulative clinical pregnancy rates over three cycles (55.4% versus 46.5%) were similar in unexplained infertility and tubal disease groups.CONCLUSIONS:
Couples with unexplained infertility failing to conceive with superovulation and IUI have a favorable outcome when treated subsequently with IVF-ET. Conception rates similar to couples with tubal disease may be expected despite a higher incidence of total fertilization failure events.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Pregnancy
/
Fertilization in Vitro
/
Embryo Transfer
/
Infertility
Type of study:
Observational_studies
/
Risk_factors_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
En
Journal:
Fertil Steril
Year:
1995
Type:
Article
Affiliation country:
Turkey