[Synthesis and antitumor activity of 4-O-(halogenated) acyl-4'-demethylepipodophyllotoxin analogues].

Yin, S F; Wang, Z G; Ma, W Y; Chen, X H; Wang, T D; Zhang, C N

Yin, S F; Wang, Z G; Ma, W Y; Chen, X H; Wang, T D; Zhang, C N.

Affiliation

Yin SF; Shanghai Institute of Pharmaceutical Industry.

Yao Xue Xue Bao ; 28(10): 758-61, 1993.

Article in Zh | MEDLINE | ID: mdl-8009987

ABSTRACT

ABSTRACT

A series of 4-(halogenated)acyl-4'-demethylepipodophyllotoxin analogues were conveniently synthesized by selective esterification in the presence of BF3.Et2O, and screened in vitro against L1210 leukemia and KB cells. Most of these compounds showed marked antitumor activity and exhibited more potent activity than that of etoposide.

Subject(s)

Podophyllotoxin/analogs & derivatives; Podophyllotoxin/chemical synthesis; Animals; Etoposide/pharmacology; Humans; KB Cells/drug effects; Leukemia L1210/pathology; Mice; Podophyllotoxin/pharmacology; Tumor Cells, Cultured/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Podophyllotoxin Limits: Animals / Humans Language: Zh Journal: Yao Xue Xue Bao Year: 1993 Type: Article

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PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Podophyllotoxin Limits: Animals / Humans Language: Zh Journal: Yao Xue Xue Bao Year: 1993 Type: Article