Prohormone processing in the trans-Golgi network: endoproteolytic cleavage of prosomatostatin and formation of nascent secretory vesicles in permeabilized cells.

Xu, H; Shields, D

Xu, H; Shields, D.

Affiliation

Xu H; Department of Anatomy and Structural Biology, Albert Einstein College of Medicine, Bronx, New York 10461.

J Cell Biol ; 122(6): 1169-84, 1993 Sep.

Article in En | MEDLINE | ID: mdl-8104189

Subject(s)

Cytoplasmic Granules/metabolism; Endopeptidases/pharmacology; Golgi Apparatus/metabolism; Pituitary Gland, Anterior/physiology; Protein Precursors/metabolism; Somatostatin/metabolism; Adenosine Triphosphate/metabolism; Adenosine Triphosphate/physiology; Animals; Biological Transport; Carbonyl Cyanide m-Chlorophenyl Hydrazone/pharmacology; Cell Line; Cell Membrane Permeability/physiology; Chloroquine/pharmacology; Chromatography, High Pressure Liquid; Cytoplasmic Granules/chemistry; Cytoplasmic Granules/physiology; Ethylmaleimide/pharmacology; Golgi Apparatus/chemistry; Guanosine 5'-O-(3-Thiotriphosphate)/pharmacology; Guanosine Triphosphate/metabolism; Guanosine Triphosphate/physiology; Hydrogen-Ion Concentration; Hydrolysis; Pituitary Gland, Anterior/chemistry; Precipitin Tests; Protein Precursors/analysis; Protein Processing, Post-Translational/physiology; Rats; Somatostatin/analysis; Temperature

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / Pituitary Gland, Anterior / Protein Precursors / Somatostatin / Cytoplasmic Granules / Golgi Apparatus Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Cell Biol Year: 1993 Type: Article

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