DNA polymorphisms of apolipoprotein B in the population of Taiwan.
J Formos Med Assoc
; 92(4): 330-5, 1993 Apr.
Article
in En
| MEDLINE
| ID: mdl-8104580
ABSTRACT
Four apolipoprotein B (apoB) genetic polymorphisms, the AluI, XbaI, MspI and EcoRI restriction fragment length polymorphisms (RFLPs), were analyzed for 162 individuals in Taiwan by polymerase chain reaction. Allele frequency determination revealed that this population has 0.86 AluI- (A-), 0.99 XbaI- (X-), 1.0 MspI+ (M+), and 0.98 EcoRI+ (E+) alleles. Major genotypes were A-/A- (0.75), X-/X- (0.98), M+/M+ (1.0) and E+/E+ (0.96). There were 0.22 A-/A+, 0.02 X-/X+ and 0.04 E+/E- heterozygous genotypes and one minor homozygous A+/A+ (0.03) genotype. The XbaI allele frequency is similar to that found in the Japanese population (XbaI- 0.96), but is significantly different from that in Caucasians (XbaI- 0.31-0.54). Significant differences (p < 0.001) between the Taiwanese and Caucasians were also observed for the AluI, EcoRI and MspI RFLP alleles of the apoB gene. More heterozygous genotypes are observed in Caucasians than in the Taiwanese.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Apolipoproteins B
/
Polymorphism, Restriction Fragment Length
Limits:
Adult
/
Aged
/
Humans
/
Middle aged
Country/Region as subject:
Asia
Language:
En
Journal:
J Formos Med Assoc
Journal subject:
MEDICINA
Year:
1993
Type:
Article