Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

Olson, L K; Redmon, J B; Towle, H C; Robertson, R P

Olson, L K; Redmon, J B; Towle, H C; Robertson, R P.

Affiliation

Olson LK; Diabetes Center, University of Minnesota Medical School, Minneapolis 55455.

J Clin Invest ; 92(1): 514-9, 1993 Jul.

Article in En | MEDLINE | ID: mdl-8326016

Subject(s)

Glucose/administration & dosage; Insulin/genetics; Islets of Langerhans/metabolism; Transcription Factors/metabolism; Animals; Base Sequence; Cell Line; Cells, Cultured; Cricetinae; DNA-Binding Proteins/metabolism; Gene Expression Regulation/drug effects; In Vitro Techniques; Molecular Sequence Data; Oligodeoxyribonucleotides/chemistry; Promoter Regions, Genetic; RNA, Messenger/genetics; Transcription, Genetic

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Islets of Langerhans / Glucose / Insulin Limits: Animals Language: En Journal: J Clin Invest Year: 1993 Type: Article

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