Oral zinc therapy in the treatment of alpha-mannosidosis.
Am J Med Genet
; 46(4): 410-4, 1993 Jun 01.
Article
in En
| MEDLINE
| ID: mdl-8357013
ABSTRACT
Human alpha-mannosidosis is a lysosomal storage disorder characterized by mental retardation, dysostosis multiplex, and hepatosplenomegaly. Deficiency of the enzyme leads to accumulation of mannose-rich glycoconjugates in tissues. Zinc sulphate has been shown to stimulate alpha-mannosidase activity in vitro. Oral zinc therapy was attempted on a 4-year-old boy with alpha-mannosidosis for 3 years. After almost 10 years of follow-up on and off zinc therapy, we must conclude that oral zinc does not substantially affect the clinical course of alpha-mannosidosis.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Zinc
/
Alpha-Mannosidosis
Type of study:
Observational_studies
/
Prognostic_studies
Limits:
Child, preschool
/
Humans
/
Male
Language:
En
Journal:
Am J Med Genet
Year:
1993
Type:
Article
Affiliation country:
Canada