A study of the nephrotoxicity of three cephalosporins in rabbits using 1H NMR spectroscopy.

Halligan, S; Byard, S J; Spencer, A J; Gray, T J; Harpur, E S; Bonner, F W

Halligan, S; Byard, S J; Spencer, A J; Gray, T J; Harpur, E S; Bonner, F W.

Affiliation

Halligan S; Department of Toxicology, Sterling Winthrop Pharmaceuticals Research Division, Alnwick, Northumberland, UK.

Toxicol Lett ; 81(1): 15-21, 1995 Nov.

Article in En | MEDLINE | ID: mdl-8525494

Subject(s)

Cephalosporins/toxicity; Kidney Tubules, Proximal/drug effects; Alanine/urine; Animals; Cefoperazone/administration & dosage; Cefoperazone/toxicity; Cephaloridine/administration & dosage; Cephaloridine/toxicity; Cephalosporins/administration & dosage; Cephalothin/administration & dosage; Cephalothin/toxicity; Citrates/urine; Citric Acid; Dose-Response Relationship, Drug; Glutamic Acid/urine; Glycine/urine; Glycosuria/urine; Hippurates/urine; Injections, Intravenous; Kidney Tubules, Proximal/pathology; Lactates/urine; Lactic Acid; Magnetic Resonance Spectroscopy; Male; Rabbits; Urinalysis/standards

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Collection: 01-internacional Database: MEDLINE Main subject: Cephalosporins / Kidney Tubules, Proximal Limits: Animals Language: En Journal: Toxicol Lett Year: 1995 Type: Article Affiliation country: United kingdom

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