Sequence 274-368 in the beta 3-subunit of the integrin alpha IIb beta 3 provides a ligand recognition and binding domain for the gamma-chain of fibrinogen that is independent of platelet activation.

Alemany, M; Concord, E; Garin, J; Vinçon, M; Giles, A; Marguerie, G; Gulino, D

Alemany, M; Concord, E; Garin, J; Vinçon, M; Giles, A; Marguerie, G; Gulino, D.

Affiliation

Alemany M; INSERM 217, Département de Biologie Moléculaire et Structurale (DBMS), Centre d'Etudes Nucléaires (CEN)-Grenoble, France.

Blood ; 87(2): 592-601, 1996 Jan 15.

Article in En | MEDLINE | ID: mdl-8555481

Subject(s)

Fibrinogen/metabolism; Platelet Glycoprotein GPIIb-IIIa Complex/chemistry; Adenosine Diphosphate/pharmacology; Alprostadil/pharmacology; Amino Acid Sequence; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacology; Binding Sites; Egtazic Acid/pharmacology; Humans; Ligands; Molecular Sequence Data; Oligopeptides/metabolism; Peptide Fragments/chemical synthesis; Peptide Fragments/genetics; Peptide Fragments/immunology; Peptide Fragments/metabolism; Platelet Activation/drug effects; Platelet Glycoprotein GPIIb-IIIa Complex/immunology; Platelet Glycoprotein GPIIb-IIIa Complex/metabolism; Protein Binding/drug effects; Recombinant Fusion Proteins/metabolism; Thrombin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: Fibrinogen / Platelet Glycoprotein GPIIb-IIIa Complex Limits: Humans Language: En Journal: Blood Year: 1996 Type: Article Affiliation country: France

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