Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation.

Hirata, T; Ushikubi, F; Kakizuka, A; Okuma, M; Narumiya, S

Hirata, T; Ushikubi, F; Kakizuka, A; Okuma, M; Narumiya, S.

Affiliation

Hirata T; Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan.

J Clin Invest ; 97(4): 949-56, 1996 Feb 15.

Article in En | MEDLINE | ID: mdl-8613548

Subject(s)

Adenylyl Cyclases/metabolism; Blood Platelets/metabolism; Point Mutation; Receptors, Thromboxane/genetics; Thromboxane A2/metabolism; Amino Acid Sequence; Base Sequence; Blood Platelets/chemistry; DNA Primers/chemistry; DNA, Complementary/genetics; Enzyme Activation; Humans; Molecular Sequence Data; Recombinant Proteins/metabolism; Signal Transduction

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thromboxane A2 / Blood Platelets / Adenylyl Cyclases / Receptors, Thromboxane / Point Mutation Type of study: Diagnostic_studies Limits: Humans Language: En Journal: J Clin Invest Year: 1996 Type: Article Affiliation country: Japan

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