Substituted 2,5'-Bi-1H-benzimidazoles: topoisomerase I inhibition and cytotoxicity.

Kim, J S; Gatto, B; Yu, C; Liu, A; Liu, L F; LaVoie, E J

Kim, J S; Gatto, B; Yu, C; Liu, A; Liu, L F; LaVoie, E J.

Affiliation

Kim JS; Department of Pharmaceutical Chemistry, Rutgers, State University of New Jersey, Piscataway, 08855, USA.

J Med Chem ; 39(4): 992-8, 1996 Feb 16.

Article in En | MEDLINE | ID: mdl-8632422

Subject(s)

Antineoplastic Agents/chemical synthesis; Benzimidazoles/chemical synthesis; Benzimidazoles/pharmacology; Enzyme Inhibitors/chemical synthesis; Topoisomerase I Inhibitors; Antineoplastic Agents/toxicity; Benzimidazoles/toxicity; Cell Line; Cell Survival/drug effects; Dose-Response Relationship, Drug; Drug Design; Enzyme Inhibitors/pharmacology; Enzyme Inhibitors/toxicity; Humans; Magnetic Resonance Spectroscopy; Molecular Structure; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzimidazoles / Enzyme Inhibitors / Topoisomerase I Inhibitors / Antineoplastic Agents Limits: Humans Language: En Journal: J Med Chem Journal subject: QUIMICA Year: 1996 Type: Article Affiliation country: United States

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