A novel PNET cell line with melanotic differentiation.
Anticancer Res
; 16(2): 779-84, 1996.
Article
in En
| MEDLINE
| ID: mdl-8687128
ABSTRACT
The primitive neuroectodermal tumor (PNET) cell line, ONS-99, was established from a human melanotic neuroectodermal tumor of infancy (MNTI). ONS-99 cells were polygonal adherent cells and transplantable to BALB/c-nu/nu mouse. ONS-99 cells were positive for NSE, HMB-45 (melanoma-associated antigen) and N-myc, but lacked the antigenic features of terminally differentiated neurons or glias. ONS-99 cells had many intermediate filaments in the cytoplasm and tight intercellular junctions with scant cytoplasmic structures by electron microscopy. To date, ONS-99 is the only example of an established PNET cell line with melanotic differentiation.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Tumor Cells, Cultured
/
Neuroectodermal Tumor, Melanotic
Limits:
Animals
/
Humans
/
Infant
/
Male
Language:
En
Journal:
Anticancer Res
Year:
1996
Type:
Article
Affiliation country:
Japan