Noninvasive imaging of herpes virus thymidine kinase gene transfer and expression: a potential method for monitoring clinical gene therapy.

Tjuvajev, J G; Finn, R; Watanabe, K; Joshi, R; Oku, T; Kennedy, J; Beattie, B; Koutcher, J; Larson, S; Blasberg, R G

Tjuvajev, J G; Finn, R; Watanabe, K; Joshi, R; Oku, T; Kennedy, J; Beattie, B; Koutcher, J; Larson, S; Blasberg, R G.

Affiliation

Tjuvajev JG; Department of Neurology, Memorial Sloan-Kettering Cancer Center, New York New York 10021, USA.

Cancer Res ; 56(18): 4087-95, 1996 Sep 15.

Article in En | MEDLINE | ID: mdl-8797571

Subject(s)

Antiviral Agents/toxicity; Ganciclovir/toxicity; Gene Transfer Techniques; Genetic Therapy; Glioma/diagnostic imaging; Mammary Neoplasms, Experimental/diagnostic imaging; Thymidine Kinase/biosynthesis; Animals; Arabinofuranosyluracil/analogs & derivatives; Arabinofuranosyluracil/chemical synthesis; Arabinofuranosyluracil/metabolism; Arabinofuranosyluracil/pharmacokinetics; Carbon Radioisotopes; Cell Line; Gamma Cameras; Glioma/enzymology; Glioma/pathology; Glioma/therapy; Immunohistochemistry/methods; Iodine Radioisotopes; Magnetic Resonance Imaging/methods; Mammary Neoplasms, Experimental/pathology; Mammary Neoplasms, Experimental/therapy; Rats; Rats, Nude; Sensitivity and Specificity; Simplexvirus; Thymidine Kinase/analysis; Thymidine Kinase/genetics; Tomography, Emission-Computed, Single-Photon/methods

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Thymidine Kinase / Genetic Therapy / Ganciclovir / Gene Transfer Techniques / Glioma / Mammary Neoplasms, Experimental Type of study: Diagnostic_studies Limits: Animals Language: En Journal: Cancer Res Year: 1996 Type: Article Affiliation country: United States

Search on Google

XML

PubMed Links