A neural substrate of hyperactivity in borna disease: changes in brain dopamine receptors.
Virology
; 222(2): 332-8, 1996 Aug 15.
Article
in En
| MEDLINE
| ID: mdl-8806517
ABSTRACT
Rats experimentally infected with the neurotropic RNA virus, Borna disease virus, have a hyperactive movement disorder. Because locomotor activity is modulated by the nucleus accumbens (N. Acc.) dopamine (DA) system, high-affinity DA uptake, DA D1, D2, and D3 receptor binding sites were examined in N. Acc. subregions of normal and infected rats by quantitative receptor autoradiography. The N. Acc. of infected rats had decreased mazindol and D2 and D3 radioligand binding in the core and decreased D3 radioligand binding in rostral subregions. The abnormalities observed in the N. Acc. DA system of infected rats may offer insights into the potential viral pathogenesis of psychiatric conditions with a dopaminergic substrate such as schizophrenia and affective disorders.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Borna Disease
/
Receptors, Dopamine
/
Nucleus Accumbens
Type of study:
Etiology_studies
Limits:
Animals
Language:
En
Journal:
Virology
Year:
1996
Type:
Article
Affiliation country:
United States