Glucosamine-induced inhibition of liver glucokinase impairs the ability of hyperglycemia to suppress endogenous glucose production.

Barzilai, N; Hawkins, M; Angelov, I; Hu, M; Rossetti, L

Barzilai, N; Hawkins, M; Angelov, I; Hu, M; Rossetti, L.

Affiliation

Barzilai N; Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Diabetes ; 45(10): 1329-35, 1996 Oct.

Article in En | MEDLINE | ID: mdl-8826967

Subject(s)

Glucokinase/antagonists & inhibitors; Glucosamine/pharmacology; Glucose/metabolism; Insulin/pharmacology; Liver/enzymology; Animals; Blood Glucose/drug effects; Blood Glucose/metabolism; Diabetes Mellitus/enzymology; Diabetes Mellitus, Experimental/enzymology; Glucagon/blood; Glucosamine/blood; Glucose Clamp Technique; Humans; Hyperglycemia/metabolism; Infusions, Intravenous; Insulin/administration & dosage; Kinetics; Lactates/blood; Male; Rats; Rats, Sprague-Dawley; Somatostatin/administration & dosage; Somatostatin/pharmacology; Uridine Diphosphate Glucose/metabolism; Uridine Diphosphate N-Acetylglucosamine/metabolism

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Collection: 01-internacional Database: MEDLINE Main subject: Glucokinase / Glucosamine / Glucose / Insulin / Liver Limits: Animals / Humans / Male Language: En Journal: Diabetes Year: 1996 Type: Article Affiliation country: United States

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