Effects of selective adenosine A1 and A2a agonists on amphetamine-induced locomotion and c-Fos in striatum and nucleus accumbens.
Brain Res
; 707(1): 75-80, 1996 Jan 22.
Article
in En
| MEDLINE
| ID: mdl-8866715
ABSTRACT
Low to moderate doses of amphetamine produce locomotion which is dependent on release of dopamine in the anteromedial striatum and nucleus accumbens. The effects of selective adenosine A1 and A2a receptor agonists on locomotion and c-Fos induction following a moderate dose of amphetamine was assessed in rats. Pretreatment with the adenosine A1 receptor agonist N6-cyclohexyladenosine (CHA) or the adenosine A2a receptor agonist 2-[(2-aminoethylamino)carbonylethylphenylethylamino]-5'-N- ethylcarboxamidoadenosine (APEC) inhibited locomotion following an injection of amphetamine (1.5 mg/kg). This dose of amphetamine induced Fos-like immunoreactivity in an antero-dorsomedial distribution in the caudate-putamen and uniformly in the core and shell of the nucleus accumbens. Pretreatment with the adenosine A2a receptor agonist APEC, but not the adenosine A1 receptor agonist CHA, attenuated c-Fos induction in caudate-putamen and nucleus accumbens by amphetamine. These findings indicate that amphetamine-induced behavior is subject to modulation by adenosine receptors through mechanisms which are both related to and independent of c-Fos induction.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Proto-Oncogene Proteins c-fos
/
Corpus Striatum
/
Purinergic P1 Receptor Agonists
/
Amphetamine
/
Locomotion
/
Nucleus Accumbens
Limits:
Animals
Language:
En
Journal:
Brain Res
Year:
1996
Type:
Article
Affiliation country:
United States