New evidence that serum beta(2)-microglobulin behaves as a biological marker of bone remodelling in women.
Eur J Clin Invest
; 26(8): 681-5, 1996 Aug.
Article
in En
| MEDLINE
| ID: mdl-8872064
ABSTRACT
Having observed that serum beta(2)-microglobulin concentration correlates with serum tartrate-resistant acid phosphatase (TRAP) concentration in postmenopausal osteoporosis, and that metacarpal endosteal diameter is dependent on bone resorption, we correlated the two biochemical parameters with the radiographic parameter to determine if beta(2)-microglobulin behaves like a biological marker of bone remodelling. In 105 women (mean age 68 +/- 4 years) consisting of 60 normal postmenopausal women and 55 osteoporotic postmenopausal women, there was a significant positive correlation between metacarpal endosteal diameter and these two biochemical values (r = 0.66 with beta(2)-microglobulin and r = 0.68 with TRAP in the osteoporotic postmenopausal women; r = 0.48 with beta(2)-microglobulin and r = 0.56 with TRAP in the normal postmenopausal women; P < 0.001 for all comparisons). All three measurements were significantly higher (P < 0.001) in the osteoporotic postmenopausal women than in the normal postmenopausal women. These findings show that serum beta(2)-microglobulin behaves like a biological marker of remodelling.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Biomarkers
/
Osteoporosis, Postmenopausal
/
Beta 2-Microglobulin
/
Bone Remodeling
Type of study:
Diagnostic_studies
Limits:
Aged
/
Female
/
Humans
/
Middle aged
Language:
En
Journal:
Eur J Clin Invest
Year:
1996
Type:
Article
Affiliation country:
Spain