Particle activity and in vivo pulmonary response to freshly milled and aged alpha-quartz.
Scand J Work Environ Health
; 21 Suppl 2: 15-8, 1995.
Article
in En
| MEDLINE
| ID: mdl-8929681
ABSTRACT
This study examined the possibility of freshly fractured alpha-quartz being more toxic and inflammatory in vivo than aged quartz of the same composition and particle size. Fresh quartz was generated by a jet mill, and used immediately, while aged dust was stored for two months before use. Both the production of hydrogen peroxide and hydroxyl radicals and the analysis of surface radicals verified the enhanced surface activity of fresh quartz. Male Fischer 344 rats were exposed to fresh or aged alpha-quartz by inhalation (20 mg center dot m-3, 5 h per day, 5 d per week, for 2 weeks) and their pulmonary responses were determined 1--3 d postexposure. Exposure to aged quartz resulted in an increase in cytotoxic and inflammatory parameters. In comparison, the inhalation of freshly cleaved quartz resulted in dramatically greater increases in all of the pulmonary responses. This finding suggests that exposure to freshly machined quartz may result in a greater risk of pulmonary disease.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Quartz
/
Bronchoalveolar Lavage Fluid
/
Lung Diseases, Interstitial
Type of study:
Etiology_studies
/
Prognostic_studies
Limits:
Animals
Language:
En
Journal:
Scand J Work Environ Health
Year:
1995
Type:
Article
Affiliation country:
United States