A major quantitative trait locus influences hyperactivity in the WKHA rat.
Nat Genet
; 14(4): 471-3, 1996 Dec.
Article
in En
| MEDLINE
| ID: mdl-8944030
ABSTRACT
The syndrome of hyperactivity describes behavioural disorders existing mainly in children and characterized by increased levels of motor activity, inattention and impulsivity. Overall the aetiology is poorly understood due to the heterogeneity of the pathology although psychological, biological and social factors acting singly or in concert are generally thought to be involved. In animal studies the observed hyperactivity phenotype results from relative participation of exploration, emotionality and general activity. Studies using brain lesions, neuropharmacology and gene knock-out strategies have shown that specific elements of the brain dopaminergic system can subserve hyperactivity. Evidence of a genetic contribution comes from family and twin studies but also from the ability to select divergent animal lines on the basis of their differential activity. The Wistar-Kyoto (WKY) and Wistar-Kyoto hyperactive (WKHA) rats are such strains--distinct for their low and high activity scores in a novel environment, respectively. Here, we report the detection of a major hyperactivity-related QTL on chromosome 8, explaining 29% of the variance of an intercross between these strains. This study represents the first behavioural QTL analysis in rat and provides a new starting point for biologically categorizing different forms of hyper-activity.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Hyperkinesis
Limits:
Animals
Language:
En
Journal:
Nat Genet
Journal subject:
GENETICA MEDICA
Year:
1996
Type:
Article
Affiliation country:
France