UKPDS 19: heterogeneity in NIDDM: separate contributions of IRS-1 and beta 3-adrenergic-receptor mutations to insulin resistance and obesity respectively with no evidence for glycogen synthase gene mutations. UK Prospective Diabetes Study.

Zhang, Y; Wat, N; Stratton, I M; Warren-Perry, M G; Orho, M; Groop, L; Turner, R C

Zhang, Y; Wat, N; Stratton, I M; Warren-Perry, M G; Orho, M; Groop, L; Turner, R C.

Affiliation

Zhang Y; Diabetes Research Laboratories, Radcliffe Infirmary, Oxford, UK.

Diabetologia ; 39(12): 1505-11, 1996 Dec.

Article in En | MEDLINE | ID: mdl-8960833

Subject(s)

Diabetes Mellitus, Type 2/genetics; Insulin Resistance/genetics; Mutation/genetics; Obesity/genetics; Phosphoproteins/genetics; Receptors, Adrenergic, beta/genetics; Adult; Alleles; Base Sequence; Cohort Studies; DNA Primers/chemistry; Diabetes Mellitus, Type 2/epidemiology; Diabetes Mellitus, Type 2/physiopathology; Glycogen Synthase/genetics; Humans; Hyperlipidemias/genetics; Insulin Receptor Substrate Proteins; Lipoprotein Lipase/genetics; Middle Aged; Obesity/ethnology; Phenotype; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length; Prevalence; Prospective Studies; Receptors, Adrenergic, beta-3; United Kingdom

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Insulin Resistance / Receptors, Adrenergic, beta / Diabetes Mellitus, Type 2 / Mutation / Obesity Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limits: Adult / Humans / Middle aged Country/Region as subject: Europa Language: En Journal: Diabetologia Year: 1996 Type: Article Affiliation country: United kingdom

Search on Google

XML

PubMed Links