Goblet cell carcinoid arising in a mature teratoma of the mediastinum.
Am J Surg Pathol
; 21(1): 109-13, 1997 Jan.
Article
in En
| MEDLINE
| ID: mdl-8990147
ABSTRACT
Goblet cell carcinoid (GCC) is a rare but distinctive neoplasm with features of both adenocarcinoma and carcinoid tumor. Most cases described in the literature have occurred in the appendix. An additional well-defined location is the ovary, and these tumors have been associated with a mature teratoma of the ovary. GCC arising within a mature teratoma of the mediastinum has not been described in the English-language literature. We report a case of this previously undescribed entity and provide a review of the literature on mediastinal teratomas with malignant transformation. The histologic findings included uniform, smooth-bordered glandular nests lined by goblet cells and admixed endocrine and Paneth cells. Occasional tubular glands were present, as were transitional type glands with both goblet cell and tubular features. Cytologic atypia was minimal, and mitotic activity was rare. Immunohistochemical studies showed positive staining of GCC tumor cells with chromogranin, cytokeratin, neuron-specific enolase, serotonin (focal), and Leu-7 (focal). The GCC component was entirely contained within the mature teratoma.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Teratoma
/
Carcinoid Tumor
/
Mediastinal Neoplasms
/
Neoplasms, Multiple Primary
Limits:
Humans
/
Male
/
Middle aged
Language:
En
Journal:
Am J Surg Pathol
Year:
1997
Type:
Article
Affiliation country:
United States