The carotenoids beta-carotene, canthaxanthin and zeaxanthin inhibit macrophage-mediated LDL oxidation.
FEBS Lett
; 401(2-3): 262-6, 1997 Jan 20.
Article
in En
| MEDLINE
| ID: mdl-9013900
ABSTRACT
Human monocyte-macrophages were incubated for 24 h in Ham's F-10 medium with human low-density lipoprotein (LDL) in the presence or absence of beta-carotene, canthaxanthin or zeaxanthin, at final concentrations of 2.5, 12.5 and 25 mg/l. LDL oxidation, measured by agarose gel electrophoresis, the thiobarbituric acid assay and gas chromatography, was inhibited by each of the carotenoids in a concentration-dependent manner. Canthaxanthin was more effective when incorporated into LDL before addition to the cultures whereas beta-carotene and zeaxanthin were more effective when added simultaneously with LDL. The results suggest that dietary carotenoids might help slow atherosclerosis progression.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Canthaxanthin
/
Beta Carotene
/
Lipoproteins, LDL
/
Macrophages
/
Antioxidants
Limits:
Humans
Language:
En
Journal:
FEBS Lett
Year:
1997
Type:
Article
Affiliation country:
United kingdom