Dietary sucrose and starch affect dysplastic characteristics in carcinogen-induced aberrant crypt foci in rat colon.
Cancer Lett
; 114(1-2): 39-41, 1997 Mar 19.
Article
in En
| MEDLINE
| ID: mdl-9103249
ABSTRACT
To study whether dietary carbohydrates affect dysplasia in aberrant crypt foci (ACF), rats treated with 1,2-dimethilhydrazine (DMH) were fed for three months with diets containing 46% sucrose or corn starch. The number of ACF/colon in the two dietary groups was similar (P = 0.58), but ACF were smaller in the starch than in sucrose group (P < 0.05). ACF in the starch group also showed less severe goblet cell dysplasia, more sulphomucins and less sialomucins than in the sucrose group (P < 0.05), indicating that corn starch protects against colon carcinogenesis while sucrose in the diet is detrimental, promoting the dysplasia of preneoplastic lesions like ACF.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Precancerous Conditions
/
Starch
/
Colonic Neoplasms
/
Dietary Sucrose
Limits:
Animals
Language:
En
Journal:
Cancer Lett
Year:
1997
Type:
Article
Affiliation country:
Italy