Vitamin C blocks inflammatory platelet-activating factor mimetics created by cigarette smoking.

Lehr, H A; Weyrich, A S; Saetzler, R K; Jurek, A; Arfors, K E; Zimmerman, G A; Prescott, S M; McIntyre, T M

Lehr, H A; Weyrich, A S; Saetzler, R K; Jurek, A; Arfors, K E; Zimmerman, G A; Prescott, S M; McIntyre, T M.

Affiliation

Lehr HA; Institute for Pathology, Johannes Gutenberg University, Mainz, Germany.

J Clin Invest ; 99(10): 2358-64, 1997 May 15.

Article in En | MEDLINE | ID: mdl-9153277

Subject(s)

Ascorbic Acid/pharmacology; Blood Platelets/physiology; Monocytes/physiology; Neutrophils/physiology; Platelet Activating Factor/analogs & derivatives; Platelet Activating Factor/physiology; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Smoking/blood; Animals; Antioxidants/pharmacology; Azepines/pharmacology; Blood Platelets/drug effects; Cell Adhesion; Cell Aggregation; Chemokine CCL4; Cricetinae; Humans; Interleukin-8/blood; Macrophage Inflammatory Proteins/blood; Monocytes/drug effects; Neutrophils/drug effects; Platelet Activating Factor/antagonists & inhibitors; Platelet Activating Factor/pharmacology; Platelet Aggregation/drug effects; Platelet Aggregation Inhibitors/pharmacology; Platelet Membrane Glycoproteins/antagonists & inhibitors; Platelet Membrane Glycoproteins/physiology; Reference Values; Time Factors; Triazoles/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ascorbic Acid / Blood Platelets / Monocytes / Platelet Activating Factor / Smoking / Receptors, Cell Surface / Receptors, G-Protein-Coupled / Neutrophils Limits: Animals / Humans Language: En Journal: J Clin Invest Year: 1997 Type: Article Affiliation country: Germany

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