Isoform switching of type IV collagen is developmentally arrested in X-linked Alport syndrome leading to increased susceptibility of renal basement membranes to endoproteolysis.

Kalluri, R; Shield, C F; Todd, P; Hudson, B G; Neilson, E G

Kalluri, R; Shield, C F; Todd, P; Hudson, B G; Neilson, E G.

Affiliation

Kalluri R; Penn Center for Molecular Studies of Kidney Diseases, Renal Electrolyte and Hypertension Division, University of Pennsylvania Medical School, Philadelphia, Pennsylvania 19104-6144, USA.

J Clin Invest ; 99(10): 2470-8, 1997 May 15.

Article in En | MEDLINE | ID: mdl-9153291

Subject(s)

Collagen/biosynthesis; Endopeptidases/metabolism; Gene Expression Regulation, Developmental; Kidney Glomerulus/metabolism; Kidney/metabolism; Nephritis, Hereditary/metabolism; X Chromosome; Basement Membrane/metabolism; Cathepsin B/metabolism; Cathepsin G; Cathepsins/metabolism; Chromatography, Ion Exchange; Collagen/isolation & purification; Collagenases/metabolism; Embryonic and Fetal Development; Humans; Kidney/embryology; Kidney/growth & development; Kidney Cortex/metabolism; Male; Nephritis, Hereditary/genetics; Pancreatic Elastase/metabolism; Reference Values; Serine Endopeptidases

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Endopeptidases / X Chromosome / Collagen / Gene Expression Regulation, Developmental / Kidney / Kidney Glomerulus / Nephritis, Hereditary Limits: Humans / Male Language: En Journal: J Clin Invest Year: 1997 Type: Article Affiliation country: United States

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