[Intraperitoneal single-dose toxicity studies of active metabolite, optical isomers, hydrolysis products and bi-product of (+/-)-4-diethylamino-1,1-dimethylbut-2-yn-1-yl 2-cyclohexyl-2-hydroxy-2-phenylacetate monohydrochloride monohydrate(NS-21), a novel drug for urinary frequency and incontinence, in mice].

Nishimura, N; Kobayashi, J; Moro, M; Katsumata, T; Nishiguchi, Y; Iwakura, K; Sumi, N

Nishimura, N; Kobayashi, J; Moro, M; Katsumata, T; Nishiguchi, Y; Iwakura, K; Sumi, N.

Affiliation

Nishimura N; Gotemba Laboratory, Bozo Research Center Inc., Shizuoka, Japan.

J Toxicol Sci ; 22 Suppl 1: 15-25, 1997 Apr.

Article in Ja | MEDLINE | ID: mdl-9170601

Subject(s)

Phenylacetates/toxicity; Urination Disorders/drug therapy; Animals; Dose-Response Relationship, Drug; Female; Hydrolysis; Injections, Intraperitoneal; Isomerism; Lethal Dose 50; Male; Mice; Molecular Structure; Phenylacetates/chemistry; Phenylacetates/metabolism; Phenylacetates/therapeutic use; Urinary Incontinence/drug therapy

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Collection: 01-internacional Database: MEDLINE Main subject: Phenylacetates / Urination Disorders Limits: Animals Language: Ja Journal: J Toxicol Sci Year: 1997 Type: Article Affiliation country: Japan

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