Semicochliodinol A and B: inhibitors of HIV-1 protease and EGF-R protein tyrosine kinase related to asterriquinones produced by the fungus Chrysosporium merdarium.

Fredenhagen, A; Petersen, F; Tintelnot-Blomley, M; Rösel, J; Mett, H; Hug, P

Fredenhagen, A; Petersen, F; Tintelnot-Blomley, M; Rösel, J; Mett, H; Hug, P.

Affiliation

Fredenhagen A; Core Drug Discovery Technologies, Ciba-Geigy Ltd., Basel, Switzerland.

J Antibiot (Tokyo) ; 50(5): 395-401, 1997 May.

Article in En | MEDLINE | ID: mdl-9207909

Subject(s)

Benzoquinones/chemistry; Benzoquinones/isolation & purification; HIV Protease Inhibitors/chemistry; HIV Protease Inhibitors/isolation & purification; Indoles/chemistry; Indoles/isolation & purification; Benzoquinones/pharmacology; Chromatography, High Pressure Liquid; Chrysosporium/metabolism; Fermentation; HIV Protease Inhibitors/pharmacology; Humans; Indoles/pharmacology; Models, Molecular; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Benzoquinones / HIV Protease Inhibitors / Indoles Type of study: Prognostic_studies Limits: Humans Language: En Journal: J Antibiot (Tokyo) Year: 1997 Type: Article Affiliation country: Switzerland

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